A.             Positions and Honors 

1981-Present              Chief of Staff, Shriners Burns Hospital, Galveston, Texas
1986-Present              Professor, Department of Surgery, University of Texas Medical Branch
1993-Present              Professor, Department of Pediatrics, University of Texas Medical Branch
1990-Present             Jesse H. Jones Distinguished Chair in Burn Surgery 

Awards and Honors: 

Outstanding Service Award, ABA Board of Trustee, 1998, Harvey Stuart Allen  Distinguished Service Award, 1998, Steve Hansen Award, Outstanding Poster Presentation, South West Assoc. of Clin. Microbiology, 1995, James IV Traveling Fellowship, International James IV, Surg. Soc., 1993, Jesse H. Jones Distinguished Chair in Surgery, 1990

B.      Publications (selected from 535 peer review articles and 93 book chapters)

1.         Wolf SE, Jeschke MG, Rose JK, Desai MH, Herndon DN.  Enteral feeding intolerance: an indicator of sepsis-associated mortality in burned children.  Arch Surg  132:1310-131, 1997.

2.         Ramirez RJ, Wolf SE, Barrow RE, Herndon DN.  Growth hormone treatment in pediatric burns: a safe therapeutic approach. Ann Surg  228:439-448, 1998.

3.         Jeschke MG, Barrow RE, Hawking H, Perez-Polo JR, Herndon DN.  Biodistribution and feasability  and mechanisms of non-viral IGF-1 gene transfer in the skin.  Lab Invest  80:1-7, 2000.

4.         Barrow RE, Jeschke MG, Herndon DN.  Early release of third-degree eyelid burns prevent eye injury.  Plast  Reconstr Surg  105:860-863, 2000.

5.         Ramzy PI, Wolf SE, Irtun O, Hart DW, Thompson JC, Herndon DN.  Gut epithelial apoptosis after severe burn: Effect of gut hypoperfusion.  J Amer Coll Surg  190:281-287, 2000.

6.         Jeschke MG, Herndon DN, Wolf SE, DebRoy MA, Rai J, Thompson JC, Barrow RE.  Hepatocyte  growth factor modulates the hepatic acute-phase response in thermally injured rats.  Crit Care Med 28(2):504-510, 2000.

7.         Barret JP, Dziewulski P, Ramzy PI, Wolf SE, Desai MH, Herndon DN.  Biobrane versus 1% silver Sulfadiazine in second-degree pediatric burns.  Plast Reconstr Surg  105:62-65, 2000.

8.         Lal SO, Wolf  SE, Herndon DN.  Growth hormone, burns and tissue healing.  Growth Horm IGF Res 10(Suppl B):S39-S43, 2000.

9.         Jeschke MG, Herndon DN, Wolf SE, DebRoy MA, Rai J, Thompson JC, Barrow RE.  Hepatocyte growth factor modulates the hepatic acute-phase response in thermally injured rats.  Crit Care Med 28(2):504-510, 2000.

10.     Hart DW, Wolf SE, Chinkes DL, Lal SO, Beauford RB, Celis M, Wolfe RR, Herndon DN.  Anti-catabolic synergism between growth hormone and propranolol after burn.  Surg Forum  51:196-197, 2000.

11.     Hart DW, Wolf SE, Mlcak R, Chinkes DL, Ramzy PI, Obeng MK, Wolfe RR, Herndon DN.  Persistence of muscle catabolism after severe burn.  Surgery 128(2):312-319, 2000.

12.     Hart DW, Wolf SE, Chinkes DL, Gore DC, Mlcak RP, Beauford RB, Obeng MK, Lal S, Gold WF, Wolfe RR, Herndon DN.  Determinants of skeletal muscle catabolism after severe burn.  Ann Surg 232(4):455-465, 2000.

13.     Gore DC, Ferrando A, Barnett J, Wolf SE, Desai M, Herndon DN, Goodwin C, Wolfe RR.  Influence of glucose kinetics on plasma lactate concentration and energy expenditure in severely burned patients.  J Trauma 49(4):673-678, 2000.

14.     Spies M, Sanford AP, Aili Low JF, Wolf SE, Herndon DN.  Treatment of extensive toxic epidermal necrolysis in children.  Pediatrics  108:1162-1168, 2001.

15.     Herndon DN, Hart DW, Wolf SE, Chinkes DL, Wolfe RR  Reversal of catabolism by beta-blockade after severe burns. N Engl J Med  345:1223-1229, 2001.

16.     Ferrando AA, Sheffield-Moore M, Wolf SE, Herndon DN, Wolfe RR.   Testosterone administration in severe burns ameliorates muscle catabolism.  Crit Care Med  29:1936-1942, 2001. 

17.     Gore DC, Chinkes D, Heggers J, Herndon DN, Wolf SE, Desai M.  Association of hyperglycemia with increased mortality after severe burn injury.  Trauma  51:540-544, 2001.

18.     Hart DW, Wolf SE, Beauford RB, Lal SO, Chinkes DL, Herndon DN.  Determinants of blood loss during primary burn excision.  Surgery 130:396-402, 2001.  Aili Low JF,

19.     Hart DW, Herndon DN, Klein G, Lee SB, Celis M, Mohan S, Chinkes DL, Wolf SE.  Attenuation of posttraumatic muscle catabolism and osteopenia by long-term growth hormone therapy. Ann Surg  233:827-834, 2001.

20.     Hart DW, Wolf SE, Ramzy PI, Chinkes DL, Beauford RB, Ferrando AA, Wolfe RR, Herndon DN.  Anabolic effects of oxandrolone after severe burn.  Ann Surg  233:556-564, 2001.

21.     Aili Low JF, Barrow RE, Mittendorfer B, Jeschke MG, Chinkes DL, Herndon DN.  The effect of short-term growth hormone treatment on growth and energy expenditure in burned children.  Burns 27:447-452, 2001.

22.     Barret JP, Jeschke MG, Herndon DN.  Selective decontamination of the digestive tract in severely burned pediatric patients.  Burns 27:439-445, 2001.

23.     Utsunomiya T, Kobayashi M, Herndon DN, Pollard RB, Suzuki F.  A mechanism of interleukin-12 unresponsiveness associated with thermal injury.  Surg Res  96:211-217, 2001.

24.     Varedi M, Chinery R, Greeley GH Jr, Herndon DN, Englander EW.  Thermal injury effects on intestinal crypt cell proliferation and death are cell position dependent.  Am J Physiol Gastrointest Liver Physiol  280:G157-G163, 2001.

25.     Thomas SJ, Morimoto K, Herndon DN, Ferrando AA, Wolfe RR, Klein GL, Wolf SE.  The effect of prolonged euglycemic hyperinsulinemia on lean body mass after severe burn.  Surgery 132:341-347, 2002.

26.     Morio B, Irtun O, Herndon DN, Wolfe RR.  Propranolol decreases splanchnic triacylglycerol storage in burn patients receiving a high-carbohydrate diet.  Ann Surg  236:218-225. 2002.

27.     Suman OE, Mlcak RP, Herndon DN.  Effect of exercise training on pulmonary function in children with thermal injury.  J Burn Care Rehabil  23):288-297,  2002.

28.     Furukawa K, Kobayashi M, Herndon DN, Pollard RB, Suzuki F.  Appearance of monocyte chemoattractant protein 1 (MCP-1) early after thermal injury: role in the subsequent development of burn-associated type 2 T-cell responses.  Ann Surg   236:112-119, 2002.

29.      Furukawa K, Kobayashi M, Sasaki H, Herndon DN, Pollard RB, Suzuki F.  Cryptococcal encephalitis in thermally injured mice is accelerated by type 2 T-cell responses.  Crit Care Med 30:1419-1424,  2002.

30.     Spies M, Wolf SE, Barrow RE, Jeschke MG, Herndon DN.  Modulation of types I and II acute phase reactants with insulin-like growth factor-1/binding protein-3 complex in severely burned children.  Crit Care Med  30:83-88, 2002.

31.      Klein GL, Langman CB, Herndon DN.  Vitamin D depletion following burn injury in children: a possible factor in post-burn osteopenia.  J Trauma  52:346-350, 2002.

32.      Angel C, Shu T, French D, Orihuela E, Lukefahr J, Herndon DN.  Genital and perineal burns in children: 10 years of experience at a major burn center.  J Pediatr Surg  37:99-103, 2002.

33.     Hart DW, Wolf SE, Herndon DN, Chinkes DL, Lal SO, Obeng MK, Beauford RB, Mlcak RT RP. Energy expenditure and caloric balance after burn: increased feeding leads to fat rather than lean mass accretion.  Ann Surg  235:152-161, 2002.
 

C.            Research Support 

Clayton Foundation for Research                                            1/1/02-12/31/02
“Medical Technologies and Product Development for Burns, Trauma, and Wound Healing.”
The focus of this grant is to develop vehicles to transport growth factors and their genes to enhance the healing rates and new skin synthesis in burned children.
Role: PI

Clayton Foundation for Research                                            1/1/02-12/31/02
“Fetal Membrane as a New Wound Coverage Material.”
The long-term goals are to develop a new, abundant, and cheaper burn wound cover that reduces sepsis, and the development of adverse scar tissue.  This skin cover can be used in conjunction with impregnated growth factors to enhance healing and reduce in hospital and outpatient times.
Role: PI

Grant Number:  1 RO1 GM56687-04
NIH                                                                                          1/1/02-12/31/04
“Modulation of the Postburn Hypermetabolic Response.”
This grant supports a study on the therapeutic efficacy of growth hormone or propranolol or a combination of both in acute burn treatment prior to initial hospital discharge on the rate of peripheral lipolysis, hepatic steatosis, lipid oxidation and secretion using a newly developed stable isotope technique to provide a new approach in treating the hypermetabolic response to a thermal injury.
This is the grant requested to be renewed.
Role: PI

Grant Number GM60338-01 (Project 1)                               4/01/01 – 3/31/05
NIH/NIGMS
“Burn Center Grant: Anabolic Agents and Muscle Protein in Burned Children.”
The focus of this grant is to investigate the effects of exercise and anabolic agents on muscle, skin, and bone in recovering burned children.  The sub-projects are interrelated and investigations will be concomitant with each patient’s return to SHC at 3, 5, 9, and 12 months post-injury.  This grant does not involve the use of anabolic  agents during acute hospitalization as proposed in the current application.
Role: Program Director and Project 1 Director                                  

Grant Number:  H133A70019
NIDRR                                                                         10/1/02-9/30/03
“Pediatric Burn Injury Rehabilitation Model System.”
The pediatric burn rehabilitation model will develop a multicenter database of longitudinal assessments of burned children to include cardiopulmonary function, growth and maturation, bone density, range of motion, scar formation, reconstruction needs and functional outcomes. This grant will provide follow-up at 3, 6, 9, 12, 18 and 24 months post burn for which no support is requested in the current application.
Role: PI

Grant Number:  8480
SHC                                                                                        1/1/02-12/31/02
“Special Shared Facilities for Clinical Research”
The overall purpose of the Special Shared Facility for Clinical Research is to support the many ongoing clinical trials by providing equipment, support staff, supplies, and laboratory space.  Data collected through these clinical trials are sorted, stratified and analyzed through the support of statistical staff, nursing staff and data retrieval personnel.
Role: PI

 Grant Number: 8660
SHC                                                                                        1/1/02-12/31/02
“Assessment of the Mechanisms of Improved Wound Healing of Anabolic Agents and Diet in Severely Burned Patients.”
A study of anabolic hormones in burned children will answer whether low dose insulin or insulin like growth-1 will attenuate muscle catabolism and improve wound healing, immunocompetence, the hepatic acute phase response and burn recovery times to provide an improved long-term recovery.
Role: PI

Grant Number: 8760                                                                1/1/02-12/31/02
SHC
“Trial to Demonstrate Safety and Efficacy of Treatment of Major Pediatric Burns with Oxandrolone and/or Resistive Cardiovascular Exercise During the First Year Post Discharge”
This is a double blinded, randomized prospective trial in burned children ages 6-19 years with burns >40%BSA, Oxandrolone, 0.2 mg/gk/day will be given to half the subjects; the others will receive a placebo.
Role: PI